The vehicles collided on the eastbound side near milepost 12 in Hardwick Township just before 9 p.m., NJSP Det. Jeffrey Lebron told Daily Voice.
Both drivers and one passenger were taken to a nearby hospital for treatment of non-life-threatening injuries, Lebron added.
The vehicles sustained disabling damage and were towed from the scene.
The crash remains under investigation. No further details were released.
Click here to follow Daily Voice North Hunterdon and receive free news updates.